Anatomy and Cell BiologySupervisor: Lilian Plotkin
- Internship Location:
- Pre Professional Interests Preferred:
Pre-Dentistry, Pre-Medicine, Pre-Nursing, Pre-Pharmacy, Pre-Veterinary Medicine
- Dress Code:
- Students should wear closed-toe shoes and comfortable clothing.
- Majors Preferred:
Biology, Chemistry, Health Sciences, Medical Humanities and Health Studies, Nursing
- Hours per week:
- Flexible within regular work hours
- The focus of this work is to understand the brain-bone connection in cognitive and behavioral diseases. Using mouse genetic models of Alzheimer's disease and fragile X syndrome, we examine the bone and muscle effect of the mutations. We measure the amount of bone and its strength, changes in the bone structure using microcomputarized tomography and microscopic examination, and changes at the gene/protein levels using molecular biology techniques.
- Internship Duties:
- Work in the lab includes analysis of bone mass and strength, scanning of bones using microcomputarized tomography machine, quantification of bone cell number and activity under the microscope, isolation of protein and RNA from bones, and analysis of particular genes and proteins by quantitative PCR and western blotting. Work might also include identification of genetically modified mice by PCR. Students will be trained in all these techniques in the lab.
- Some biology and basic chemistry are preferable.