Medicine (Hematology/Oncology) and Cellular and Integrative PhysiologyMentor Name: Heather O'Leary
- Internship Location:
- Dress Code:
- Closed-toe shoes
- Majors Preferred:
Biology, Biotechnology, Health Sciences
- Hours per week:
- Flexible within regular work hours
- We study normal and cancer blood cells and how understanding their native environment can help us pick better therapeutic targets. Normal and malignant (cancerous) blood cells reside in environments where the native oxygen (O2) levels are significantly lower than the room air we breathe (~3% O2 compared to ~21% O2, respectively). These cells are important to study as 1) normal blood cells are clinically used in transplantation to cure disease, and 2) understanding how malignant cells differ from normal cells allows us to identify pathways and develop drugs to specifically target and destroy malignant cells while leaving the normal cells intact. Therefore, we developed novel technology to study normal and malignant cells in their native low 02 to determine how it influences how they grow/divide/behave/function and to identify novel pathway/signals used for survival/function in the body that may be lost at room air O2.
- Internship Duties:
- Cell culture, experiments, collaborating with post-doc and technician, flow cytometry, data analysis, and potential assistance with animal experiments.
- Enthusiasm for learning and science.